Nicotine is not known to cause cancer. It is approved for use in nicotine replacement therapies, such as the patch or nicotine gum. However, there are risks linked to nicotine and it is a highly addictive substance. As well, exposure to nicotine from smoking is known to contribute to increased heart rate and blood pressure and to cardiovascular disease, and it is suspected that nicotine exposure from vaping has similar long-term cardiovascular effects.
Vaping products contain nicotine in various concentrations, compared to more standardized amounts found in cigarettes and nicotine replacement therapy. Some products contain much higher levels of nicotine than cigarettes. A single Juul pod can contain as much nicotine as an entire pack of cigarettes, and delivers this nicotine much faster and more intensely than smoking. The effects of these concentrations and inhaling nicotine aerosol are still being studied.
Vaping with nicotine can also lead to side effects like seizures or blackouts, due to inhaling too much nicotine in a short period of time. This is considered a form of nicotine poisoning. The majority of incidences have been among youth so far, according to US-based reports.